This uncoupling allows the evolution of new genes, both within gene families and also allelic forms of a gene. 这一耦联允许新基因的形成，不论是在基因家族内还是以某个基因的等位基因形式。
Hepatocarcinogenesis is strongly linked to increases in allelic losses, chromosomal changes,gene mutations, epigenetic alterations and alterations in molecular cellular pathways. 肝癌的形成与等位基因丢失，染色体改变，基因突变，分子细胞通路改变关系密切。
