Past history review showed neonatal hypotonia, feeding difficulty with cyanosis, and poor activity. 过去史显示新生儿期会有低肌肉张力，喂食困难，及活力差的现象。
For those infants with an abnormal neurological examination, MRI may be useful for diagnosis of PVL in spite of normal ultrasound findings during the newborn period. 对于新生儿期脑部超音波检查正常之婴儿，如果神经学检查有不正常之发现，脑部磁振摄影可用来诊断脑室周围白质软化症。
