Noun:

1. action that makes a problem or a disease (or its symptoms) worse;

   "the aggravation of her condition resulted from lack of care"
   

2. violent and bitter exasperation;

   "his foolishness was followed by an exacerbation of their quarrel"
   

exasperationn.让人恼怒的事；被激怒的状态

aggravationn.更恶化；加厉；恼怒；恼人的事

1. A consequence of the new trends, then, is exacerbation of the already disturbing backlog problem.
   因此，新趋势的后果之一，是使本来已经非常严峻的积案问题更加恶化。
2. After delivery, no patient underwent the abnormal liver function or liver disease progression or exacerbation.
   分娩后，无一例病人肝功能异常或肝病恶化。